Identify and comprehensively characterise the potential common and country-specific risk factors underlying high cervical and oesophageal cancer incidences and mortality rates in South Africa, Brazil, China, India and Tanzania.
Define the RNA and splicing landscape of cervical and oesophageal cancers to determine whether splicing and expression alterations differ between and among populations from Low- Middle Income Countries (LMICs) and developed countries by comparing patient samples from South Africa, China, India, Brazil and Tanzania.
Investigate the therapeutic potential of miRNAs and their mRNA and pathway targets in HIV-associated cervical and oesophageal cancer.
Conduct pre-clinical and clinical trials of natural products to investigate the anti- tumour and anti-metastasis efficacy using tumour grafts (TGs) or patient derived xenografts (PDXs).
