Profiling Science

SAMRC’s COVID-19 research, funding and innovations - Video

/research-for-our-people/samrcs-covid-19-research-funding-and-innovations

SAMRC Jerusalema Challenge

/research-for-our-people/samrc-jerusalema-challenge

Researchers are calling for greater regulation of the alcohol industry

/research-for-our-people/researchers-are-calling-greater-regulation-alcohol-industry

COVID-19 Research

/research-for-our-people/covid-19-research

Metformin and heart failure–related outcomes in patients with or without diabetes: a systematic review of randomized controlled trials

Dludla PV, Nyambuya TM, Johnson R, Silvestri S, Orlando P, Mazibuko-Mbeje SE, Gabuza KB, Mxinwa V, Mokgalaboni K, Tiano L, Muller CJF, Louw J, Nkambule BB.

https://pubmed.ncbi.nlm.nih.gov/32157481/

/research-for-our-people/metformin-and-heart-failure%E2%80%93related-outcomes-patients-or-without-diabetes

Exploring the comparative efficacy of metformin and resveratrol in the management of diabetes-associated complications: a systematic review of preclinical studies

Dludla PV, Silvestri S, Orlando P, Gabuza KB, Mazibuko-Mbeje SE, Nyambuya TM, Mxinwa V, Mokgalaboni K, Johnson R, Muller CJF, Tiano L, Louw J, Nkambule BB.

https://pubmed.ncbi.nlm.nih.gov/32168855/

/research-for-our-people/exploring-comparative-efficacy-metformin-and-resveratrol-management-diabetes

Recent developments with advancing gene therapy to treat chronic infection with hepatitis B virus

Maepa MB, Jacobs R, van den Berg F, Arbuthnot P

https://pubmed.ncbi.nlm.nih.gov/32141890/

/research-for-our-people/recent-developments-advancing-gene-therapy-treat-chronic-infection-hepatitis

Health workers’ perceptions and experiences of using mHealth technologies to deliver primary healthcare services: a qualitative evidence synthesis

Odendaal WA, Leon N, Goudge J, Griffiths F, Tomlinson M, Daniels K

https://pubmed.ncbi.nlm.nih.gov/32216074/

/research-for-our-people/health-workers%E2%80%99-perceptions-and-experiences-using-mhealth-technologies

Maternal and infant outcomes among pregnant women treated for multidrug/rifampicin-resistant tuberculosis in South Africa

Loveday M, Hughes J, Sunkari B, Master I, Hlangu S, Reddy T, Chotoo S, Green N, Seddon JA

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa189/5788430

/research-for-our-people/maternal-and-infant-outcomes-among-pregnant-women-treated

Mycobacterium tuberculosis and myeloid-derived suppressor cells: Insights into caveolin rich lipid rafts

Kotzé LA, Young C, Leukes VN, John V, Fang Z, Walzl G, Lutz MB, du Plessis N

https://pubmed.ncbi.nlm.nih.gov/32113158/

/research-for-our-people/mycobacterium-tuberculosis-and-myeloid-derived-suppressor-cells-insights

Novel techniques for detection of mycobacterium bovis infection in a cheetah

Kerr TJ, Gumbo R, Goosen WJ, Rogers P, Last RD, Miller MA

https://wwwnc.cdc.gov/eid/article/26/3/19-1542_article

/research-for-our-people/novel-techniques-detection-mycobacterium-bovis-infection-cheetah

Dihydrocodeine for detoxification and maintenance treatment in individuals with opiate use disorders

Carney T, van Hout MC, Norman I, Dada S, Siegfried N, Parry CDH

https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012254.pub2/full

/research-for-our-people/dihydrocodeine-detoxification-and-maintenance-treatment-individuals-opiate

A landscape of genomic alterations at the root of a near-untreatable tuberculosis epidemic

Klopper M, Heupink TH, Hill-Cawthorne G, Streicher EM, Dippenaar A, de Vos M, Abdallah AM, Limberis J, Merker M, Burns S, Niemann S, Dheda K, Posey J, Pain A, Warren RM.

https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-019-1487-2

/research-for-our-people/landscape-genomic-alterations-root-near-untreatable-tuberculosis-epidemic

Xpert MTB/RIF Ultra and Xpert MTB/RIF for diagnosis of tuberculosis in an HIVendemic setting with a high burden of previous tuberculosis: a two-cohort diagnostic accuracy study

Mishra H, Reeve BWP, Palmer Z, Caldwell J, Dolby T, Naidoo CC, Jackson JG, Schumacher SG, Denkinger CM, Diacon AH, van Helden PD, Marx FM, Warren RM, Theron G.

https://pubmed.ncbi.nlm.nih.gov/32066534/

/research-for-our-people/xpert-mtbrif-ultra-and-xpert-mtbrif-diagnosis-tuberculosis-hivendemic

Mental, behavioral and neurodevelopmental disorders in the ICD-11: an international perspective on key changes and controversies

Stein DJ, Szatmari P, Gaebel W, Berk M, Vieta E, Maj M, de Vries YA, Roest AM, de Jonge P, Maercker A, Brewin CR, Pike KM, Grilo CM, Fineberg NA, Briken P, Cohen-Kettenis PT, Reed GM.

https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-020-1495-2

/research-for-our-people/mental-behavioral-and-neurodevelopmental-disorders-icd-11-international

Immunogenicity and safety of different dosing schedules of trivalent inactivated influenza vaccine in pregnant women with HIV

Nunes MC, Cutland CL, Moultrie A, Jones S, Ortiz JR, Neuzil KM, Klugman KP, Simões EAF, Weinberg A, Madhi SA, Hugo A, Sithole P, Stoltenkamp LA, Abdoola Y, van Niekerk N, Treurnicht F.

https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(19)30322-4/fulltext

/research-for-our-people/immunogenicity-and-safety-different-dosing-schedules-trivalent-inactivated

Expanding our understanding of the triglyceride paradox in populations of African ancestry

Goedecke JH

https://pubmed.ncbi.nlm.nih.gov/31895657/

/research-for-our-people/expanding-our-understanding-triglyceride-paradox-populations-african

Structural determinants of gender inequality: why they matter for adolescent girls' sexual and reproductive health

George AS, Amin A, De Abreu Lopes CM, Ravindran TKS

https://www.bmj.com/content/368/bmj.l6985

/research-for-our-people/structural-determinants-gender-inequality-why-they-matter-adolescent-girls

Careful governance of African biobanks

Christoffels A, Abayomi A

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32624-8/fulltext

/research-for-our-people/careful-governance-african-biobanks

Process elements contributing to community mobilization for HIV risk reduction and gender equality in rural South Africa

MacPhail C, Khoza N, Treves-Kagan S, Selin A, Gómez-Olivé X, Peacock D, Rebombo D, Twine R, Maman S, Kahn K, DeLong SM, Hill LM, Lippman SA, Pettifor A.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0225694

/research-for-our-people/process-elements-contributing-community-mobilization-hiv-risk-reduction-and

Immunogenicity and safety of fractional dose yellow fever vaccination: a systematic review and meta-analysis

Nnaji CA, Shey MS, Adetokunboh OO, Wiysonge CS.

https://www.sciencedirect.com/science/article/pii/S0264410X19316603

/research-for-our-people/immunogenicity-and-safety-fractional-dose-yellow-fever-vaccination

Liver is widely eaten by preschool children in the Northern Cape province of South Africa: implications for routine vitamin A supplementation

van Stuijvenberg ME, Schoeman SE, Nel J, le Roux M, Dhansay MA.

https://onlinelibrary.wiley.com/doi/full/10.1111/mcn.12931

/research-for-our-people/liver-widely-eaten-preschool-children-northern-cape-province-south-africa

Service providers perceptions of barriers to the implementation of trauma-focused substance use services for women in Cape Town, South Africa

Myers B, Carney T, Johnson K, Browne FA, Wechsberg WM.

https://www.ncbi.nlm.nih.gov/pubmed/31830616

/research-for-our-people/service-providers-perceptions-barriers-implementation-trauma-focused

Negative association of interleukin-33 plasma levels and schistosomiasis infection in a site of polyparasitism in rural Cameroon

Kamdem SD, Konhawa F, Kuemkon EM, Meyo Kamguia L, Tchanana GK, Nche F, Oumarou A, Hamza M, Ouratou Y, Tcheutchoua MN, Ghislain Essomba R, Ngogang MP, Kengne M, Netongo PM, Ondigui BE, Okomo Assoumou MC, Brombacher F, Nono JK

https://www.frontiersin.org/articles/10.3389/fimmu.2019.02827/full

/research-for-our-people/negative-association-interleukin-33-plasma-levels-and-schistosomiasis

The gut microbiome in tuberculosis susceptibility and treatment response: guilty or not guilty?

Eribo OA, du Plessis N, Ozturk M, Guler R, Walzl G, Chegou NN

https://www.ncbi.nlm.nih.gov/pubmed/31729564

/research-for-our-people/gut-microbiome-tuberculosis-susceptibility-and-treatment-response-guilty-or

Therapeutic host-directed strategies to improve outcome in tuberculosis

Young C, Walzl G, Du Plessis N

https://www.nature.com/articles/s41385-019-0226-5.pdf?proof=true

/research-for-our-people/therapeutic-host-directed-strategies-improve-outcome-tuberculosis

Strengthening quality of care for children who are HEU

Goga A.

https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(19)30497-8/fulltext

/research-for-our-people/strengthening-quality-care-children-who-are-heu

Effect of co-trimoxazole prophylaxis on morbidity and mortality of HIV-exposed, HIV-uninfected infants in South Africa: a randomised controlled, non-inferiority trial

Daniels B, Coutsoudis A, Moodley-Govender E, Mulol H, Spooner E, Kiepiela P, Reddy S, Zako L, Ho N, Kuhn L, Ramjee G.

https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(19)30422-X/fulltext

/research-for-our-people/effect-co-trimoxazole-prophylaxis-morbidity-and-mortality-hiv-exposed-hiv

Mycobacterium tuberculosis: concentrate resources on recent infections.

van Helden PD, Hoal EG.

https://www.bmj.com/content/367/bmj.l6485

/research-for-our-people/mycobacterium-tuberculosis-concentrate-resources-recent-infections

An observational pilot study evaluating the utility of minimally invasive tissue sampling to determine the cause of stillbirths in South African women

Madhi SA, Pathirana J, Baillie V, Cutland C, Adam Y, Izu A, Bassat Q, Blau DM, Breiman RF, Hale M, Johnstone S, Martines RB, Mathunjwa A, Nzenze S, Ordi J, Raghunathan PL, Ritter JM, Solomon F, Wadula J, Zaki SR, Chawana R.

https://www.ncbi.nlm.nih.gov/pubmed/31598656

/research-for-our-people/observational-pilot-study-evaluating-utility-minimally-invasive-tissue

Unraveling specific causes of neonatal mortality using minimally invasive tissue sampling: an observational study

Madhi SA, Pathirana J, Baillie V, Izu A, Bassat Q, Blau DM, Breiman RF, Hale M, Mathunjwa A, Martines RB, Nakwa FL, Nzenze S, Ordi J, Raghunathan PL, Ritter JM, Solomon F, Velaphi S, Wadula J, Zaki SR, Chawana R.

https://www.ncbi.nlm.nih.gov/pubmed/31598660

/research-for-our-people/unraveling-specific-causes-neonatal-mortality-using-minimally-invasive

Potential of minimally invasive tissue sampling for attributing specific causes of childhood deaths in South Africa: a pilot, epidemiological study

Chawana R, Baillie V, Izu A, Solomon F, Bassat Q, Blau DM, Breiman RF, Hale M, Houpt ER, Lala SG, Martines RB, Mathunjwa A, Nzenze S, Pathirana J, Petersen KL, Raghunathan PL, Ritter JM, Wadula J, Zaki SR, Madhi SA.

https://academic.oup.com/cid/article/69/Supplement_4/S361/5584381

/research-for-our-people/potential-minimally-invasive-tissue-sampling-attributing-specific-causes

High rates of drug-induced liver injury in people living with HIV coinfected with Tuberculosis irrespective of antiretroviral therapy timing during antituberculosis treatment: results from the starting antiretroviral therapy at three points in TB trial

Naidoo K, Hassan-Moosa R, Mlotshwa P, Yende-Zuma N, Govender D, Padayatchi N, Abdool-Karim SSS.

https://www.ncbi.nlm.nih.gov/pubmed/31622456

/research-for-our-people/high-rates-drug-induced-liver-injury-people-living-hiv-coinfected

Time to strengthen HIV treatment and prevention for youth

Pettifor A, Filiatreau L, Delaney-Moretlwa S.

https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(19)30232-2/fulltext

/research-for-our-people/time-strengthen-hiv-treatment-and-prevention-youth

HIV incidence rates in adolescent girls and young women in sub-Saharan Africa

Karim SSA, Baxter C.

https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(19)30404-8/fulltext

/research-for-our-people/hiv-incidence-rates-adolescent-girls-and-young-women-sub-saharan-africa

Social media and HPV vaccination: unsolicited public comments on a Facebook post by the Western Cape Department of Health provide insights into determinants of vaccine hesitancy in South Africa

Wiyeh AB, Cooper S, Jaca A, Mavundza E, Ndwandwe D, Wiysonge CS.

https://www.ncbi.nlm.nih.gov/pubmed/31521412

/research-for-our-people/social-media-and-hpv-vaccination-unsolicited-public-comments-facebook-post

Factors that influence acceptance of human papillomavirus (HPV) vaccination for adolescents: a qualitative evidence synthesis

Cooper S, Schmidt BM, Ryan J, Leon N, Mavundza E, Burnett R, Tanywe AC, Wiysonge CS.

https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013430/references

/research-for-our-people/factors-influence-acceptance-human-papillomavirus-hpv-vaccination

Progression to type 2 diabetes mellitus and associated risk factors after hyperglycemia first detected in pregnancy: a cross-sectional study in Cape Town, South Africa

Chivese T, Norris SA, Levitt NS.

https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002865

/research-for-our-people/progression-type-2-diabetes-mellitus-and-associated-risk-factors-after

Immune correlates of the Thai RV144 HIV vaccine regimen in South Africa.

Gray GE, Huang Y, Grunenberg N, Laher F, Roux S, Andersen-Nissen E, De Rosa SC, Flach B, Randhawa AK, Jensen R, Swann EM, Bekker L-G, Innes C, Lazarus E, Morris L, Mkhize NN, Ferrari G, Montefiori DC, Shen X, Sawant S, Yates N, Hural J, Isaacs A, Phogat S, DiazGranados CA, Lee C, Sinangil F, Michael NL, Robb ML, Kublin JG, Gilbert PB, McElrath MJ, Tomaras GD, Corey L.

https://stm.sciencemag.org/content/11/510/eaax1880

/research-for-our-people/immune-correlates-thai-rv144-hiv-vaccine-regimen-south-africa

The Lancet Respiratory Medicine Commission: 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and incurable tuberculosis

Dheda K, Gumbo T, Maartens G, Dooley KE, Murray M, Furin J, Nardell EA, Warren RM, The Lancet Respiratory Medicine drug-resistant tuberculosis Commission group.

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(19)30263-2/fulltext

/research-for-our-people/lancet-respiratory-medicine-commission-2019-update-epidemiology-pathogenesis

Participation of traditional, complementary and alternative health practitioners in conventional health systems in low‐ and middle‐income countries

Street R, Falkenberg T, Sundberg T, Balakrishna Y, Abrams A, Kredo T.

https://www.cochrane.org/CD013391/EPOC_participation-traditional-complementary-and-alternative-health-practitioners-conventional-health

/research-for-our-people/participation-traditional-complementary-and-alternative-health-practitioners

Breastfeeding, HIV exposure, childhood obesity, and prehypertension: a South African cohort study

Houle B, Rochat TJ, Newell ML, Stein A, Bland RM.

https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002889

/research-for-our-people/breastfeeding-hiv-exposure-childhood-obesity-and-prehypertension-south

Tuberculosis diagnosis in children using Xpert ultra on different respiratory specimens

Zar HJ, Workman LJ, Prins M, Bateman LJ, Mbhele SP, Whitman CB, Denkinger CM, Nicol MP.

https://www.ncbi.nlm.nih.gov/pubmed/31381861

/research-for-our-people/tuberculosis-diagnosis-children-using-xpert-ultra-different-respiratory

Unmasking the vulnerabilities of uninfected children exposed to HIV

Ramokolo V, Goga AE, Slogrove AL, Powis KM.

https://www.bmj.com/content/366/bmj.l4479

/research-for-our-people/unmasking-vulnerabilities-uninfected-children-exposed-hiv

Obsessive-compulsive disorder

Stein DJ, Costa DLC, Lochner C, Miguel EC, Reddy YCJ, Shavitt RG, van den Heuvel OA, Simpson HB.

https://www.nature.com/articles/s41572-019-0102-3

/research-for-our-people/obsessive-compulsive-disorder

Validations of verbal autopsies - Comment on 'automated versus physician assignment of cause of death for verbal autopsies: Randomized trial of 9374 deaths in 117 villages in India'

Garenne M.

https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-019-1371-0

/research-for-our-people/validations-verbal-autopsies-comment-automated-versus-physician-assignment

Improving outcomes in patients with non-tuberculous mycobacterial disease: is there light at the end of the tunnel?

Dheda K.

https://erj.ersjournals.com/content/54/1/1901149.abstract

/research-for-our-people/improving-outcomes-patients-non-tuberculous-mycobacterial-disease-there

Management of active tuberculosis in adults with HIV

Meintjes G, Brust JCM, Nuttall J, Maartens G.

https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(19)30154-7/fulltext

/research-for-our-people/management-active-tuberculosis-adults-hiv

Differential burden of peripheral artery disease

Kengne AP, Echouffo-Tcheugui JB.

https://www.thelancet.com/pdfs/journals/langlo/PIIS2214-109X(19)30293-1.pdf

/research-for-our-people/differential-burden-peripheral-artery-disease

Harnessing biological insight to accelerate tuberculosis drug discovery

de Wet TJ, Warner DF, Mizrahi V.

https://pubs.acs.org/doi/abs/10.1021/acs.accounts.9b00275

/research-for-our-people/harnessing-biological-insight-accelerate-tuberculosis-drug-discovery

Trends, patterns and determinants of long-acting reversible methods of contraception among women in sub-Saharan Africa

Adedini SA, Omisakin OA, Somefun OD.

https://www.ncbi.nlm.nih.gov/pubmed/31163050

/research-for-our-people/trends-patterns-and-determinants-long-acting-reversible-methods

A cross sectional analytic study of modes of delivery and caesarean section rates in a private health insured South African population

Solanki G, Fawcus S, Daviaud E.

https://www.ncbi.nlm.nih.gov/pubmed/31247013

/research-for-our-people/cross-sectional-analytic-study-modes-delivery-and-caesarean-section-rates

HIV-1 drug resistance surveillance among parturient women on anti-retroviral therapy in the Eastern Cape, South Africa: implications for elimination of mother-to-child transmission.

Adeniyi OV, Obi CL, Goon DT, Iweriebor B, Ajayi AI, Lambert J, Okoh A.

https://www.ncbi.nlm.nih.gov/pubmed/31255794

/research-for-our-people/hiv-1-drug-resistance-surveillance-among-parturient-women-anti-retroviral

Workplace violence in Bangladesh's garment industry

Gibbs A, Jewkes R, Willan S, Al Mamun M, Parvin K, Yu M, Naved R.

https://www.ncbi.nlm.nih.gov/pubmed/31260817

/research-for-our-people/workplace-violence-bangladeshs-garment-industry

Occurrence and risk evaluation of organochlorine contaminants in surface water along the course of Swartkops and Sundays River Estuaries, Eastern Cape Province, South Africa

Olisah C, Adeniji AO, Okoh OO, Okoh AI.

https://www.ncbi.nlm.nih.gov/pubmed/31177475

/research-for-our-people/occurrence-and-risk-evaluation-organochlorine-contaminants-surface-water

Response by Naidoo et al to letter regarding article "Early life factors and longitudinal blood pressure trajectories are associated with elevated blood pressure in early adulthood: BT20 Cohort"

Naidoo S, Kagura J, Fabian J, Norris SA.

https://www.ncbi.nlm.nih.gov/pubmed/31067204

/research-for-our-people/response-naidoo-et-al-letter-regarding-article-early-life-factors-and

More research is needed on digital technologies in violence against women

Jewkes R, Dartnall E.

https://www.sciencedirect.com/science/article/pii/S2468266719300763?via%3Dihub

/research-for-our-people/more-research-needed-digital-technologies-violence-against-women

Point of care Xpert MTB/RIF versus smear microscopy for tuberculosis diagnosis in southern African primary care clinics: a multicentre economic evaluation

Pooran A, Theron G, Zijenah L, Chanda D, Clowes P, Mwenge L, Mutenherwa F, Lecesse P, Metcalfe J, Sohn H, Hoelscher M, Pym A, Peter J, Dowdy D, Dheda K.

https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(19)30164-0/fulltext

/research-for-our-people/point-care-xpert-mtbrif-versus-smear-microscopy-tuberculosis-diagnosis

Low birthweight: will new estimates accelerate progress?

Doherty T, Kinney M.

https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(19)30041-5/fulltext

/research-for-our-people/low-birthweight-will-new-estimates-accelerate-progress

Gender equality and health: laying the foundations for change

George AS, Amin A, GarcIa-Moreno C, Sen G.

https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(19)30987-0.pdf

/research-for-our-people/gender-equality-and-health-laying-foundations-change

Decriminalisation of recreational cannabis in South Africa

Parry C, Myers B, Caulkins J.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)30011-X/fulltext

/research-for-our-people/decriminalisation-recreational-cannabis-south-africa

The emerging role of myeloid-derived suppressor cells in tuberculosis.

Magcwebeba T, Dorhoi A, du Plessis N.

https://www.frontiersin.org/articles/10.3389/fimmu.2019.00917/full

/research-for-our-people/emerging-role-myeloid-derived-suppressor-cells-tuberculosis

Synthesis and structure-activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH

Singh V, Pacitto A, Donini S, Ferraris DM, Boros S, Illyes E, Szokol B, Rizzi M, Blundell TL, Ascher DB, Pato J, Mizrahi V.

https://www.sciencedirect.com/science/article/pii/S0223523419303332

/research-for-our-people/synthesis-and-structure-activity-relationship-1-5

Longitudinal changes in spirometry in perinatally HIV-infected South African adolescents on antiretroviral therapy

Githinji LN, Gray DM, Hlengwa S, Machemedze T, Zar HJ.

https://www.ncbi.nlm.nih.gov/pubmed/30938406

/research-for-our-people/longitudinal-changes-spirometry-perinatally-hiv-infected-south-african

Understanding the full clinical spectrum of childhood diarrhoea in low-income and middle-income countries.

Groome MJ, Parashar UD.

https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(19)30056-7/fulltext

/research-for-our-people/understanding-full-clinical-spectrum-childhood-diarrhoea-low-income-and

The duopoly of ten-valent and 13-valent pneumococcal conjugate vaccines: do they differ?

Madhi SA, Goldblatt D.Madhi SA, Goldblatt D.

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(18)30785-0/fulltext

/research-for-our-people/duopoly-ten-valent-and-13-valent-pneumococcal-conjugate-vaccines-do-they

SAMRC research on Femicide and Child homicide

Prof. Naeemah Abrahams & Bianca Dekel

http://www.samrc.ac.za/intramural-research-units/GenderHealth-current-projects

/research-for-our-people/samrc-research-femicide-and-child-homicide

Lower respiratory tract infections in children in a well-vaccinated South African birth cohort: spectrum of disease and risk factors

le Roux DM, Nicol MP, Myer L, Vanker A, Stadler JAM, von Delft E, Zar HJ.

https://www.ncbi.nlm.nih.gov/pubmed/30925191

/research-for-our-people/lower-respiratory-tract-infections-children-well-vaccinated-south-african

Antiretroviral switching and bedaquiline treatment of drug-resistant tuberculosis HIV co-infection

O'Donnell MR, Padayatchi N, Daftary A, Orrell C, Dooley KE, Rivet Amico K, Friedland G.

https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(19)30035-9/fulltext

/research-for-our-people/antiretroviral-switching-and-bedaquiline-treatment-drug-resistant

The microbiome and tuberculosis: state of the art, potential applications, and defining the clinical research agenda

Naidoo CC, Nyawo GR, Wu BG, Walzl G, Warren RM, Segal LN, Theron G.

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(18)30501-0/fulltext

/research-for-our-people/microbiome-and-tuberculosis-state-art-potential-applications-and-defining

How are countries in sub-Saharan African monitoring the impact of programmes to prevent vertical transmission of HIV?

Goga A, Singh Y, Jackson D, Mukungunugwa S, Wafula R, Eliya M, Ng'ambi WF, Nabitaka L, Chirinda W, Bhardwaj S, Essajee S, Hayashi C, Pillay Y.

https://www.bmj.com/content/364/bmj.l660

/research-for-our-people/how-are-countries-sub-saharan-african-monitoring-impact-programmes-prevent

The STREAM trial: missed opportunities and lessons for future clinical trials

Loveday M, Reuter A, Furin J, Seddon JA, Cox H.

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(19)30106-9/fulltext

/research-for-our-people/stream-trial-missed-opportunities-and-lessons-future-clinical-trials

Factors that influence parents' and informal caregivers' acceptance of routine childhood vaccination: a qualitative evidence synthesis

Cooper S, Schmidt BM, Sambala EZ, Swartz A, Colvin CJ, Leon N, Betsch C, Wiysonge CS.

https://www.cochrane.org/CD013265/EPOC_factors-influence-parents-and-informal-caregivers-acceptance-routine-childhood-vaccination

/research-for-our-people/factors-influence-parents-and-informal-caregivers-acceptance-routine

A moxifloxacinbased regimen for the treatment of recurrent drug-sensitive pulmonary tuberculosis: an open-label randomised controlled trial.

Perumal R, Padayatchi N, Yende-Zuma N, Naidoo A, Govender D, Naidoo K.

https://www.ncbi.nlm.nih.gov/pubmed/30809633

/research-for-our-people/moxifloxacinbased-regimen-treatment-recurrent-drug-sensitive-pulmonary

Improving breastfeeding practices at scale

Rollins N, Doherty T.

https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(18)30557-6/fulltext

/research-for-our-people/improving-breastfeeding-practices-scale

Expanding the anti-TB arsenal

Mizrahi V, Warner DF.

https://science.sciencemag.org/content/363/6426/457

/research-for-our-people/expanding-anti-tb-arsenal-science

Engaging men to support women in science, medicine, and global health

Ratele K, Verma R, Cruz S, Khan AR.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)30031-5/fulltext

/research-for-our-people/engaging-men-support-women-science-medicine-and-global-health

The African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension (African-PREDICT): design, recruitment and initial examination

Schutte AE, Gona PN, Delles C, Uys AS, Burger A, Mels CM, Kruger R, Smith W, Fourie CM, Botha S, Lammertyn L, van Rooyen JM, Gafane-Matemane LF, Mokwatsi GG, Breet Y, Kruger HS, Zyl TV, Pieters M, Zandberg L, Louw R, Moss SJ, Khumalo IP, Huisman HW.

https://www.ncbi.nlm.nih.gov/pubmed/30681377

/research-for-our-people/african-prospective-study-early-detection-and-identification-cardiovascular

Interaction of herbal products with prescribed medications: a systematic review and meta-analysis

Awortwe C, Bruckmueller H, Cascorbi I.

https://www.ncbi.nlm.nih.gov/pubmed/30660822

/research-for-our-people/interaction-herbal-products-prescribed-medications-systematic-review-and

Prevalence of congenital cytomegalovirus infection and associated risk of in-utero HIV acquisition in a high HIV prevalence setting, South Africa

Pathirana J, Groome M, Dorfman J, Kwatra G, Boppana S, Cutland C, Jones S, Madhi SA.

https://www.ncbi.nlm.nih.gov/pubmed/30615106

/research-for-our-people/prevalence-congenital-cytomegalovirus-infection-and-associated-risk-utero

Hope for patients with X-linked hypophosphataemia?

Pettifor JM.

https://www.thelancet.com/journals/landia/article/PIIS2213-8587(19)30004-X/fulltext

/research-for-our-people/hope-patients-x-linked-hypophosphataemia

Integrating mental health with other non-communicable diseases

Stein DJ, Benjet C, Gureje O, Lund C, Scott KM, Poznyak V, van Ommeren M

https://www.bmj.com/content/364/bmj.l295

/research-for-our-people/integrating-mental-health-other-non-communicable-diseases

Inflammation and oxidative stress in an obese state and the protective effects of gallic acid

Dludla PV, Nkambule BB, Jack B, Mkandla Z, Mutize T, Silvestri S, Orlando P, Tiano L, Louw J, Mazibuko-Mbeje SE.

https://www.ncbi.nlm.nih.gov/pubmed/30577684

/research-for-our-people/inflammation-and-oxidative-stress-obese-state-and-protective-effects-gallic

Early Life factors and longitudinal blood pressure trajectories are associated with elevated blood pressure in early adulthood

Naidoo S, Kagura J, Fabian J, Norris SA.

https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.11992

/research-for-our-people/early-life-factors-and-longitudinal-blood-pressure-trajectories-are

Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases

Guler R, Mpotje T, Ozturk M, Nono JK, Parihar SP, Chia JE, Abdel Aziz N, Hlaka L, Kumar S, Roy S, Penn-Nicholson A, Hanekom WA, Zak DE, Scriba TJ, Suzuki H, Brombacher F.

https://www.ncbi.nlm.nih.gov/pubmed/30542107

/research-for-our-people/batf2-differentially-regulates-tissue-immunopathology-type-1-and-type-2

Conservation of white rhinoceroses threatened by bovine tuberculosis, South Africa, 2016-2017

Miller MA, Buss P, Parsons SDC, Roos E, Chileshe J, Goosen WJ, van Schalkwyk L, de Klerk-Lorist LM, Hofmeyr M, Hausler G, Rossouw L, Manamela T, Mitchell EP, Warren R, van Helden P.

https://wwwnc.cdc.gov/eid/article/24/12/18-0293_article

/research-for-our-people/conservation-white-rhinoceroses-threatened-bovine-tuberculosis-south-africa

Urgency for South Africa to prioritise cardiovascular disease management

Schutte AE.

https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(18)30476-5/fulltext

/research-for-our-people/urgency-south-africa-prioritise-cardiovascular-disease-management

Host regulators of liver fibrosis during human schistosomiasis

Kamdem SD, Moyou-Somo R, Brombacher F, Nono JK.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279936/

/research-for-our-people/host-regulators-liver-fibrosis-during-human-schistosomiasis

Neutrophils: Innate effectors of tb resistance?

Kroon EE, Coussens AK, Kinnear C, Orlova M, Moller M, Seeger A, Wilkinson RJ, Hoal EG, Schurr E.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246713/

/research-for-our-people/neutrophils-innate-effectors-tb-resistance

Screening strategies for hypertension

Schmidt BM, Durao S, Toews I, Bavuma CM, Meerpohl JJ, Kredo T.

https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013212/full

/research-for-our-people/screening-strategies-hypertension

Measles immunity at 4.5 years of age following vaccination at 9 and 15-18 months of age among HIV-infected, HIV-exposed-uninfected and HIV-unexposed children

Mutsaerts E, Nunes MC, van Rijswijk MN, Klipstein-Grobusch K, Otwombe K, Cotton MF, Violari A, Madhi SA.

https://www.ncbi.nlm.nih.gov/pubmed/30418528

/research-for-our-people/measles-immunity-45-years-age-following-vaccination-9-and-15-18-months-age

Birth HIV testing and paediatric treatment programmes

Goga A.

https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(18)30291-1/fulltext

/research-for-our-people/birth-hiv-testing-and-paediatric-treatment-programmes

Intra-breath measures of respiratory mechanics in healthy African infants detect risk of respiratory illness in early life

Gray DM, Czovek D, McMillan L, Turkovic L, Stadler JAM, Vanker A, Radics BL, Gingl Z, Hall GL, Sly PD, Zar HJ, Hantos Z.

https://www.ncbi.nlm.nih.gov/pubmed/30464010

/research-for-our-people/intra-breath-measures-respiratory-mechanics-healthy-african-infants-detect

Silver nanoparticles mediated by Callistemon citrinus extracts and their antimalaria, antitrypanosoma and antibacterial efficacy

Larayetan R, Ojemaye MO, Okoh OO, Okoh AI.

https://www.researchgate.net/publication/328128963_Silver_nanoparticles_mediated_by_Callistemon_citrinus_extracts_and_their_antimalaria_antitrypanosoma_and_antibacterial_efficacy

/research-for-our-people/silver-nanoparticles-mediated-callistemon-citrinus-extracts-and-their

Protective effect of triterpenes against diabetes-induced beta-cell damage: an overview of in vitro and in vivo studies

Mabhida SE, Dludla PV, Johnson R, Ndlovu M, Louw J, Opoku AR, Mosa RA.

https://www.ncbi.nlm.nih.gov/pubmed/30315968

/research-for-our-people/protective-effect-triterpenes-against-diabetes-induced-beta-cell-damage

Village community mobilization is associated with reduced HIV incidence in young South African women participating in the HPTN 068 study cohort

Lippman SA, Leddy AM, Neilands TB, Ahern J, MacPhail C, Wagner RG, Peacock D, Twine R, Goin DE, Gomez-Olive FX, Selin A, Tollman SM, Kahn K, Pettifor A.

https://www.ncbi.nlm.nih.gov/pubmed/30334377

/research-for-our-people/village-community-mobilization-associated-reduced-hiv-incidence-young-south

Schistosomiasis burden and its association with lower measles vaccine responses in school children from rural Cameroon

Nono JK, Kamdem SD, Netongo PM, Dabee S, Schomaker M, Oumarou A, Brombacher F, Moyou-Somo R.

https://www.ncbi.nlm.nih.gov/pubmed/30356757

/research-for-our-people/schistosomiasis-burden-and-its-association-lower-measles-vaccine-responses

The Foxp3+ regulatory T-cell population requires IL-4Ralpha signaling to control inflammation during helminth infections.

Abdel Aziz N, Nono JK, Mpotje T, Brombacher F.

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2005850

/research-for-our-people/foxp3-regulatory-t-cell-population-requires-il-4ralpha-signaling-control

Uncoupling proteins as a therapeutic target to protect the diabetic heart

Dludla PV, Nkambule BB, Tiano L, Louw J, Jastroch M, Mazibuko-Mbeje SE

https://www.ncbi.nlm.nih.gov/pubmed/3022308

/research-for-our-people/uncoupling-proteins-therapeutic-target-protect-diabetic-heart

Genetic resistance to mycobacterium tuberculosis infection and disease

Möller M, Kinnear CJ, Orlova M, Kroon EE, van Helden PD, Schurr E, Hoal EG

https://www.ncbi.nlm.nih.gov/pubmed/30319657

/research-for-our-people/genetic-resistance-mycobacterium-tuberculosis-infection-and-disease

Death of Mycobacterium tuberculosis by l-arginine starvation

Mizrahi V, Warner DF

http://www.pnas.org/content/115/39/9658

/research-for-our-people/death-mycobacterium-tuberculosis-l-arginine-starvation

Treatment of bronchiectasis exacerbations in children: which antibiotic?

Zar HJ, Nicol MP

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32004-X/fulltext

/research-for-our-people/treatment-bronchiectasis-exacerbations-children-which-antibiotic

The coming of age of drug-susceptibility testing for tuberculosis

Cox H, Mizrahi V

https://www.nejm.org/doi/full/10.1056/NEJMe1811861?query=recirc_inIssue_bottom_article

/research-for-our-people/coming-age-drug-susceptibility-testing-tuberculosis

Genetic risk score for adult body mass index associations with childhood and adolescent weight gain in an African population

Munthali RJ, Sahibdeen V, Kagura J, Hendry LM, Norris SA, Ong KK, Day FR, Lombard Z

https://www.ncbi.nlm.nih.gov/pubmed/30123368

/research-for-our-people/genetic-risk-score-adult-body-mass-index-associations-childhood-and

Metacarpal indices and their association with fracture in South African children and adolescents

Magan A, Micklesfield LK, Norris SA, Thandrayen K, Munthali RJ, Pettifor JM

https://www.ncbi.nlm.nih.gov/pubmed/30167746

/research-for-our-people/metacarpal-indices-and-their-association-fracture-south-african-children-and

Lanosteryl triterpenes from Protorhus longifolia as a cardioprotective agent: a mini review.

Sangweni NF, Dludla PV, Mosa RA, Kappo AP, Opoku A, Muller CJF, Johnson R

https://www.ncbi.nlm.nih.gov/pubmed/30167929

/research-for-our-people/lanosteryl-triterpenes-protorhus-longifolia-cardioprotective-agent-mini

Determination of levels of some metal contaminants in the freshwater environments of Osun State, Southwest Nigeria: a risk assessment approach to predict health threat

Titilawo Y, Adeniji A, Adeniyi M, Okoh A

https://www.ncbi.nlm.nih.gov/pubmed/30103138

/research-for-our-people/determination-levels-some-metal-contaminants-freshwater-environments-osun

Concentrations of arsenic and lead in residential garden soil from four Johannesburg neighborhoods

Mathee A, Kootbodien T, Kapwata T, Naicker N

https://www.ncbi.nlm.nih.gov/pubmed/30142628

/research-for-our-people/concentrations-arsenic-and-lead-residential-garden-soil-four-johannesburg

Tracking trends in HIV/AIDS mortality pre-and-post ART: South Africa 1997 to 2012

Pillay-van Wyk V, Bradshaw D, Msemburi W, Dorrington R, Laubscher R, Groenewald P

https://onlinelibrary.wiley.com/doi/10.1002/jia2.25148

/research-for-our-people/tracking-trends-hivaids-mortality-pre-and-post-art-south-africa-1997-2012

Community mobilization to modify harmful gender norms and reduce HIV risk: results from a community cluster randomized trial in South Africa

Pettifor A, Lippman SA, Gottert A, Suchindran CM, Selin A, Peacock D, Maman S, Rebombo D, Twine R, Gomez-Olive FX, Tollman S, Kahn K, MacPhail C

https://www.ncbi.nlm.nih.gov/pubmed/29972287

/research-for-our-people/community-mobilization-modify-harmful-gender-norms-and-reduce-hiv-risk

The potential use of rifabutin for treatment of patients diagnosed with rifampicin-resistant tuberculosis

Whitfield MG, Warren RM, Mathys V, Scott L, de Vos E, Stevens W, Streicher EM, Groenen G, Sirgel FA, van Rie A

https://www.ncbi.nlm.nih.gov/pubmed/29982641

/research-for-our-people/potential-use-rifabutin-treatment-patients-diagnosed-rifampicin-resistant

Susceptibility to tuberculosis is associated with PI3K-dependent increased mobilization of neutrophils

Leisching GR

https://www.ncbi.nlm.nih.gov/pubmed/30065729

/research-for-our-people/susceptibility-tuberculosis-associated-pi3k-dependent-increased-mobilization

Role of district health management teams in child health strategies

Doherty T, Tran N, Sanders D, Dalglish SL, Hipgrave D, Rasanathan K, Sundararaman T, Ved R, Mason E

https://www.bmj.com/content/362/bmj.k2823

/research-for-our-people/role-district-health-management-teams-child-health-strategies

Drug permeation and metabolism in Mycobacterium tuberculosis: Prioritising local exposure as essential criterion in new TB drug development.

Tanner L, Denti P, Wiesner L, Warner DF.

https://www.ncbi.nlm.nih.gov/pubmed/29934964

/research-for-our-people/drug-permeation-and-metabolism-mycobacterium-tuberculosis-prioritising-local

Bicomponent fibres for controlled release of volatile mosquito repellents.

Sibanda M, Focke W, Braack L, Leuteritz A, Brünig H, Tran NHA, Wieczorek F, Trümper W.

https://www.ncbi.nlm.nih.gov/pubmed/30033310

/research-for-our-people/bicomponent-fibres-controlled-release-volatile-mosquito-repellents

Targeted pregnancy and HIV prevention risk-reduction counselling for young women: Lessons learned from biomedical prevention trials

Ramjee G, Dassaye R, Reddy T, Wand H.

https://academic.oup.com/jid/advance-article-abstract/doi/10.1093/infdis/jiy388/5045583?redirectedFrom=fulltext

/research-for-our-people/targeted-pregnancy-and-hiv-prevention-risk-reduction-counselling-young-women

Describing the diurnal relationships between objectively measured mother and infant physical activity.

Prioreschi A, Brage S, Westgate K, Micklesfield LK.

https://ijbnpa.biomedcentral.com/articles/10.1186/s12966-018-0692-2

/research-for-our-people/describing-diurnal-relationships-between-objectively-measured-mother-and

Drug-resistant tuberculosis: challenges and opportunities for diagnosis and treatment.

Koch A, Cox H, Mizrahi V.

https://www.ncbi.nlm.nih.gov/pubmed/29885623

/research-for-our-people/drug-resistant-tuberculosis-challenges-and-opportunities-diagnosis-and

Autosomal dominant IFN-γR1 deficiency presenting with both atypical mycobacteriosis and tuberculosis in a BCG-vaccinated South African patient.

Glanzmann B, Moller M, Moncada-Velez M, Peter J, Urban M, van Helden PD, Hoal EG, de Villiers N, Glashoff RH, Nortje R, Bustamante J, Abel L, Casanova JL, Boisson-Dupuis S, Esser M, Kinnear CJ.

https://www.ncbi.nlm.nih.gov/pubmed/29777412

/research-for-our-people/autosomal-dominant-ifn-%CE%B3r1-deficiency-presenting-both-atypical

What are the financial implications of the 2017 AHA/ACC high blood pressure guideline?

Schutte AE.

https://www.ncbi.nlm.nih.gov/pubmed/29785883

/research-for-our-people/what-are-financial-implications-2017-ahaacc-high-blood-pressure-guideline

Factors Influencing the umbilical cord blood stem cell industry: An evolving treatment landscape.

Dessels C, Alessandrini M, Pepper MS.

https://www.ncbi.nlm.nih.gov/pubmed/29777574

/research-for-our-people/factors-influencing-umbilical-cord-blood-stem-cell-industry-evolving

Iron loading, alcohol and mortality: A prospective study.

Schutte R, Huisman H, Mels CMC, Botha S, Kruger R, Smith W, Kruger IM, Hawkins M, Smith L, Breet Y, Schutte AE.

https://www.ncbi.nlm.nih.gov/pubmed/29803668

/research-for-our-people/iron-loading-alcohol-and-mortality-prospective-study

Challenges of cardiovascular disease risk evaluation in people living with HIV infection.

Kengne AP, Ntsekhe M.

https://www.ahajournals.org/doi/abs/10.1161/circulationaha.118.033913

/research-for-our-people/challenges-cardiovascular-disease-risk-evaluation-people-living-hiv

Prevalence and risk factors for child mental disorders in a population-based cohort of HIV-exposed and unexposed African children aged 7-11 years.

Rochat TJ, Houle B, Stein A, Pearson RM, Bland RM.

https://www.ncbi.nlm.nih.gov/pubmed/29680970

/research-for-our-people/prevalence-and-risk-factors-child-mental-disorders-population-based-cohort

Risk of nephrotoxicity in patients with drug-resistant tuberculosis treated with Kanamycin/Capreomycin with or without concomitant use of tenofovir-containing antiretroviral therapy.

Perumal R, Abdelghani N, Naidu N, Yende-Zuma N, Dawood H, Naidoo K, Singh N, Padayatchi N.

https://www.ncbi.nlm.nih.gov/pubmed/29683992

/research-for-our-people/risk-nephrotoxicity-patients-drug-resistant-tuberculosis-treated

C-type lectin receptors in asthma.

Hadebe S, Brombacher F, Brown GD.

https://www.ncbi.nlm.nih.gov/pubmed/29696023

/research-for-our-people/c-type-lectin-receptors-asthma

Tobacco cessation in low- and middle-income countries: Some challenges and opportunities.

Peer N, Kengne AP.

https://www.ncbi.nlm.nih.gov/pubmed/29663631

/research-for-our-people/tobacco-cessation-low-and-middle-income-countries-some-challenges-and

Contracting out to improve the use of clinical health services and health outcomes in Low- and Middle-Income Countries.

Odendaal WA, Ward K, Uneke J, Uro-Chukwu H, Chitama D, Balakrishna Y, Kredo T.

https://www.ncbi.nlm.nih.gov/pubmed/29611869

/research-for-our-people/contracting-out-improve-use-clinical-health-services-and-health-outcomes-low

The Effects of School-Based Condom Availability Programs (CAPs) on Condom Acquisition, Use and Sexual Behavior: A Systematic Review

Timothy Wang, Mark Lurie, Darshini Govindasamy, Catherine Mathews

https://link.springer.com/article/10.1007%2Fs10461-017-1787-5

/research-for-our-people/effects-school-based-condom-availability-programs-caps-condom-acquisition

From symptom discovery to treatment - women's pathways to breast cancer care: A cross-sectional study

Moodley J, Cairncross L, Naiker T, Constant D

https://www.ncbi.nlm.nih.gov/pubmed/29562894

/research-for-our-people/symptom-discovery-treatment-womens-pathways-breast-cancer-care-cross

Seroprevalence of mycobacterium bovis infection in warthogs (phacochoerus africanus) in bovine tuberculosis-endemic regions of South Africa

Roos EO, Olea-Popelka F, Buss P, de Klerk-Lorist LM, Cooper D, van Helden PD, Parsons SDC, Miller MA

https://www.ncbi.nlm.nih.gov/pubmed/29520985

/research-for-our-people/seroprevalence-mycobacterium-bovis-infection-warthogs-phacochoerus-africanus

The prevalence of gestational diabetes mellitus amongst black South African women is a public health concern

Macaulay S, Ngobeni M, Dunger DB, Norris SA.

https://www.ncbi.nlm.nih.gov/pubmed/29526682

/research-for-our-people/prevalence-gestational-diabetes-mellitus-amongst-black-south-african-women

Fate and impact of phthalates in activated sludge treated municipal wastewater on the water bodies in the Eastern Cape, South Africa

Salaudeen T, Okoh O, Agunbiade F, Okoh A

https://www.ncbi.nlm.nih.gov/pubmed/29626811

/research-for-our-people/fate-and-impact-phthalates-activated-sludge-treated-municipal-wastewater

Mycobacterium tuberculosis

Koch A, Mizrahi V

https://www.cell.com/trends/microbiology/fulltext/S0966-842X(18)30048-9

/research-for-our-people/mycobacterium-tuberculosis

OAS1, 2 and 3: Significance during active TB?

Leisching G, Wiid I, Baker B

https://www.ncbi.nlm.nih.gov/pubmed/29452387

/research-for-our-people/oas1-2-and-3-significance-during-active-tb

Priming the tuberculosis drug pipeline: New antimycobacterial targets and agents

Evans JC, Mizrahi V

https://www.ncbi.nlm.nih.gov/pubmed/29482115

/research-for-our-people/priming-tuberculosis-drug-pipeline-new-antimycobacterial-targets-and-agents

Mitigating the effect of persistent postnatal depression on child outcomes through an intervention to treat depression and improve parenting: A randomised controlled trial

Stein A, Netsi E, Lawrence PJ, Granger C, Kempton C, Craske MG, Nickless A, Mollison J, Stewart DA, Rapa E, West V, Scerif G, Cooper PJ, Murray L

https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(18)30006-3/fulltext

/research-for-our-people/mitigating-effect-persistent-postnatal-depression-child-outcomes-through

Developmental origins of health and disease in Africa-influencing early life

Davies JI, Macnab AJ, Byass P, Norris SA, Nyirenda M, Singhal A, Sobngwi E, Daar AS.

https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(18)30036-6/fulltext

/research-for-our-people/developmental-origins-health-and-disease-africa-influencing-early-life

Modifiable stroke risk factors in Africa: Lessons from siren

Kengne AP, Mayosi BM.

https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(18)30030-5/abstract

/research-for-our-people/modifiable-stroke-risk-factors-africa-lessons-siren

Genetic diversity and potential routes of transmission of mycobacterium bovis in Mozambique

Machado A, Rito T, Ghebremichael S, Muhate N, Maxhuza G, Macuamule C, Moiane I, Macucule B, Marranangumbe AS, Baptista J, Manguele J, Koivula T, Streicher EM, Warren RM, Kallenius G, van Helden P, Correia-Neves M.

http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006147

/research-for-our-people/genetic-diversity-and-potential-routes-transmission-mycobacterium-bovis

House dust mite induced allergic airway disease is attenuated in CD11c(CRE)IL-4Ralpha(-/L) degrees (X) mice

Nieuwenhuizen NE, Kirstein F, Hoving JC, Brombacher F

https://www.ncbi.nlm.nih.gov/pubmed/29343807

/research-for-our-people/house-dust-mite-induced-allergic-airway-disease-attenuated-cd11ccreil

Alterations in male reproductive hormones in relation to environmental DDT exposure

Bornman M, Delport R, Farías P, Aneck-Hahn N, Patrick S, Millar RP, de Jager C.

https://www.ncbi.nlm.nih.gov/pubmed/29373146

/research-for-our-people/alterations-male-reproductive-hormones-relation-environmental-ddt-exposure

Cohort PROFILE: Health and ageing in Africa: A longitudinal study of an INDEPTH community in South Africa

Gomez-Olive FX, Montana L, Wagner RG, Kabudula CW, Rohr JK, Kahn K, Barnighausen T, Collinson M, Canning D, Gaziano T, Salomon JA, Payne CF, Wade A, Tollman SM, Berkman L.

https://academic.oup.com/ije/article-abstract/47/3/689/4791962?redirectedFrom=fulltext

/research-for-our-people/cohort-profile-health-and-ageing-africa-longitudinal-study-indepth-community

Renewing the focus on health care for sexually assaulted children and adolescents

Jewkes R.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)33362-7/abstract?code=lancet-site

/research-for-our-people/renewing-focus-health-care-sexually-assaulted-children-and-adolescents

Support for alcohol policies among drinkers in Mongolia, New Zealand, Peru, South Africa, St Kitts and Nevis, Thailand and Vietnam: Data from the international alcohol control study

Parry CDH, Londani M, Enkhtuya P, Huckle T, Piazza M, Gray-Phillip G, Chaiyasong S, Viet Cuong P, Casswell S

https://www.ncbi.nlm.nih.gov/pubmed/29266725

/research-for-our-people/support-alcohol-policies-among-drinkers-mongolia-new-zealand-peru-south

Rotavirus strain diversity in eastern and southern African countries before and after vaccine introduction

Seheri LM, Magagula NB, Peenze I, Rakau K, Ndadza A, Mwenda JM, Weldegebriel G, Steele AD, Mphahlele MJ

https://www.sciencedirect.com/science/article/pii/S0264410X17316791

/research-for-our-people/rotavirus-strain-diversity-eastern-and-southern-african-countries-and-after

Describing objectively measured physical activity levels, patterns, and correlates in a cross sectional sample of infants and toddlers from South Africa

Prioreschi A, Brage S, Hesketh KD, Hnatiuk J, Westgate K, Micklesfield LK

https://www.ncbi.nlm.nih.gov/pubmed/29273035

/research-for-our-people/describing-objectively-measured-physical-activity-levels-patterns-and

APP-supported promotion of child growth and development by community health workers in Kenya: Feasibility and acceptability study

van Heerden A, Sen D, Desmond C, Louw J, Richter L

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736876/

/research-for-our-people/app-supported-promotion-child-growth-and-development-community-health

Burden of respiratory syncytial virus infection in South African HIV-infected and HIV-uninfected pregnant and post-partum women: A longitudinal cohort study

Madhi SA, Cutland CL, Downs S, Jones S, van Niekerk N, Simoes EAF, Nunes MC

https://www.ncbi.nlm.nih.gov/pubmed/29253090

/research-for-our-people/burden-respiratory-syncytial-virus-infection-south-african-hiv-infected-and

Exchange transfusions for extreme hypertriglyceridemia in a 7-week-old infant with multi-organ failure

Ghoor S, Berlyn P, Brey N

https://www.ncbi.nlm.nih.gov/pubmed/29174071

/research-for-our-people/exchange-transfusions-extreme-hypertriglyceridemia-7-week-old-infant-multi

A systematic review of the efficacy and safety of intrapericardial fibrinolysis in patients with pericardial effusion

Wiyeh AB, Ochodo EA, Wiysonge CS, Kakia A, Awotedu AA, Ristic A, Mayosi BM

https://www.ncbi.nlm.nih.gov/pubmed/29107356

/research-for-our-people/systematic-review-efficacy-and-safety-intrapericardial-fibrinolysis-patients

Exome sequencing identifies a novel MAP3K14 mutation in recessive atypical combined immunodeficiency

Schlechter N, Glanzmann B, Hoal EG, Schoeman M, Petersen BS, Franke A, Lau YL, Urban M, van Helden PD, Esser MM, Moller M, Kinnear C

https://www.ncbi.nlm.nih.gov/pubmed/29230214

/research-for-our-people/exome-sequencing-identifies-novel-map3k14-mutation-recessive-atypical

Interleukin-4 Receptor Alpha: From innate to adaptive immunity in murine models of cutaneous leishmaniasis

Hurdayal R, Brombacher F

https://www.ncbi.nlm.nih.gov/pubmed/29176972

/research-for-our-people/interleukin-4-receptor-alpha-innate-adaptive-immunity-murine-models

Neuroimaging genomics in psychiatry-a translational approach. Genome Medicine

Mufford MS, Stein DJ, Dalvie S, Groenewold NA, Thompson PM, Jahanshad N.

https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0496-z

/research-for-our-people/neuroimaging-genomics-psychiatry-translational-approach-genome-medicine

Reduction of in utero lead exposures in South African populations: Positive impact of unleaded petrol

Rollin HB, Olutola B, Channa K, Odland JO

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186445

/research-for-our-people/reduction-utero-lead-exposures-south-african-populations-positive-impact

Spatial distribution of extensively drug-resistant tuberculosis (XDR TB) patients in KwaZulu-Natal, South Africa

Kapwata T, Morris N, Campbell A, Mthiyane T, Mpangase P, Nelson KN, Allana S, Brust JCM, Moodley P, Mlisana K, Gandhi NR, Shah NS

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181797

/research-for-our-people/spatial-distribution-extensively-drug-resistant-tuberculosis-xdr-tb-patients

Point-of-care chest ultrasound in South African children with suspected pulmonary tuberculosis

Heuvelings CC, Belard S, Andronikou S, Jamieson-Luff N, Grobusch M, Zar H.

http://onlinelibrary.wiley.com/doi/10.1111/tmi.12978/epdf

/research-for-our-people/point-care-chest-ultrasound-south-african-children-suspected-pulmonary

Innovation at the intersection of alcohol and HIV research

van Heerden A, Tomlinson M, Skeen S, Parry C, Bryant K, Rotheram-Borus MJ.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660130/

/research-for-our-people/innovation-intersection-alcohol-and-hiv-research

High prevalence of HIV and Non-Communicable Disease (NCD) risk factors in rural KwaZulu-Natal, South Africa

van Heerden A, Barnabas RV, Norris SA, Micklesfield LK, van Rooyen H, Celum C.

http://onlinelibrary.wiley.com/doi/10.1002/jia2.25012/abstract

/research-for-our-people/high-prevalence-hiv-and-non-communicable-disease-ncd-risk-factors-rural

Is 24-hour central blood pressure superior to 24-hour brachial blood pressure for predicting organ damage?

Schutte AE, Laurent S.

http://hyper.ahajournals.org/content/early/2017/10/20/HYPERTENSIONAHA.117.10024

/research-for-our-people/24-hour-central-blood-pressure-superior-24-hour-brachial-blood-pressure

Financial arrangements for health systems in low-income countries: An overview of systematic reviews

Wiysonge CS, Paulsen E, Lewin S, Ciapponi A, Herrera CA, Opiyo N, Pantoja T, Rada G, Oxman AD

https://www.ncbi.nlm.nih.gov/pubmed/28891235

/research-for-our-people/financial-arrangements-health-systems-low-income-countries-overview

The association between elevated blood lead levels and violent behavior during late adolescence: The South African Birth to Twenty Plus cohort

Nkomo P, Mathee A, Naicker N, Galpin J, Richter LM, Norris SA

https://www.ncbi.nlm.nih.gov/pubmed/28916132

/research-for-our-people/association-between-elevated-blood-lead-levels-and-violent-behavior-during

Women's and men's reports of past-year prevalence of intimate partner violence and rape and women's risk factors for intimate partner violence: A multicountry cross-sectional study in Asia and the Pacific

Jewkes R, Fulu E, Tabassam Naved R, Chirwa E, Dunkle K, Haardorfer R, Garcia-Moreno C

http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002381

/research-for-our-people/womens-and-mens-reports-past-year-prevalence-intimate-partner-violence-and

IL-4-producing B cells regulate T helper cell dichotomy in type 1- and type 2-controlled diseases

Hurdayal R, Ndlovu HH, Revaz-Breton M, Parihar SP, Nono JK, Govender M, Brombacher F

https://www.ncbi.nlm.nih.gov/pubmed/28916732

/research-for-our-people/il-4-producing-b-cells-regulate-t-helper-cell-dichotomy-type-1-and-type-2

Nine-valent human papillomavirus vaccine: Great science, but will it save lives?

Denny L

https://www.ncbi.nlm.nih.gov/pubmed/28886906

/research-for-our-people/nine-valent-human-papillomavirus-vaccine-great-science-will-it-save-lives

Protein Kinase C-Delta (PKCDELTA), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice

Parihar SP, Ozturk M, Marakalala MJ, Loots DT, Hurdayal R, Beukes D, Van Reenen M, Zak DE, Mbandi SK, Darboe F, Penn-Nicholson A, Hanekom WA, Leitges M, Scriba TJ, Guler R, Brombacher F.

https://www.ncbi.nlm.nih.gov/pubmed/28832027

/research-for-our-people/protein-kinase-c-delta-pkcdelta-marker-inflammation-and-tuberculosis-disease

Cohort profile: The Siyakhula Cohort, rural South Africa

Rochat TJ, Houle B, Stein A, Pearson RM, Newell ML, Bland RM

https://www.ncbi.nlm.nih.gov/pubmed/29025088

/research-for-our-people/cohort-profile-siyakhula-cohort-rural-south-africa

The Amagugu intervention for disclosure of maternal HIV to uninfected primary school-aged children in South Africa: A randomised controlled trial

Rochat TJ, Stein A, Cortina-Borja M, Tanser F, Bland RM

https://www.ncbi.nlm.nih.gov/pubmed/28843988

/research-for-our-people/amagugu-intervention-disclosure-maternal-hiv-uninfected-primary-school-aged

Socioeconomic differences in mortality in the antiretroviral therapy era in Agincourt, rural South Africa, 2001-13: A population surveillance analysis

Kabudula CW, Houle B, Collinson MA, Kahn K, Gomez-Olive FX, Tollman S, Clark SJ

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559644/

/research-for-our-people/socioeconomic-differences-mortality-antiretroviral-therapy-era-agincourt

Mortality and socioeconomic status: The vicious cycle between poverty and ill health.

Pillay-van Wyk V, Bradshaw D

http://www.thelancet.com/journals/langlo/article/PIIS2214-109X(17)30304-2/fulltext

/research-for-our-people/mortality-and-socioeconomic-status-vicious-cycle-between-poverty-and-ill

Comparison of traditional culture and molecular QPCR for detection of simultaneous carriage of multiple pneumococcal serotypes in African children

Olwagen CP, Adrian PV, Madhi SA

https://www.ncbi.nlm.nih.gov/pubmed/28680083

/research-for-our-people/comparison-traditional-culture-and-molecular-qpcr-detection-simultaneous

Susceptibility of mycobacterium tuberculosis cytochrome bd oxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c

Moosa A, Lamprecht DA, Arora K, Barry CE 3rd, Boshoff HIM, Ioerger TR, Steyn AJC, Mizrahi V, Warner DF.

https://www.ncbi.nlm.nih.gov/pubmed/28760899

/research-for-our-people/susceptibility-mycobacterium-tuberculosis-cytochrome-bd-oxidase-mutants

Cochrane corner: Beta-blockers for hypertension

Wiysonge CS, Bradley HA, Volmink J, Mayosi BM.

http://heart.bmj.com/content/early/2017/07/29/heartjnl-2017-311585

/research-for-our-people/cochrane-corner-beta-blockers-hypertension

The cross-national epidemiology of social anxiety disorder: Data from the world mental health survey initiative

Stein DJ, Lim CCW, Roest AM, de Jonge P, Aguilar-Gaxiola S, Al-Hamzawi A, Alonso J, Benjet C, Bromet EJ, Bruffaerts R, de Girolamo G, Florescu S, Gureje O, Haro JM, Harris MG, He Y, Hinkov H, Horiguchi I, Hu C, Karam A, Karam EG, Lee S, Lepine JP, Navarro-Mateu F, Pennell BE, Piazza M, Posada-Villa J, Ten Have M, Torres Y, Viana MC, Wojtyniak B, Xavier M, Kessler RC, Scott KM

https://www.ncbi.nlm.nih.gov/pubmed/28756776

/research-for-our-people/cross-national-epidemiology-social-anxiety-disorder-data-world-mental-health

Advances in the diagnosis of pneumonia in children

Zar HJ, Andronikou S, Nicol MP

http://www.bmj.com/content/358/bmj.j2739

/research-for-our-people/advances-diagnosis-pneumonia-children

Living arrangements, disability and gender of older adults among rural South Africa

Schatz E, Ralston M, Madhavan S, Collinson MA, Gomez-Olive FX

https://www.ncbi.nlm.nih.gov/pubmed/28651372

/research-for-our-people/living-arrangements-disability-and-gender-older-adults-among-rural-south

Sugary beverage taxation in South Africa: Household expenditure, demand system elasticities, and policy implications

Stacey N, Tugendhaft A, Hofman K.

https://www.ncbi.nlm.nih.gov/pubmed/28579502

/research-for-our-people/sugary-beverage-taxation-south-africa-household-expenditure-demand-system

Interleukin-4 receptor alpha is still required after Th2 polarization for the maintenance and the recall of protective immunity to Nematode infection

Nono JK, Ndlovu H, Abdel Aziz N, Mpotje T, Hlaka L, Brombacher F.

http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005675

/research-for-our-people/interleukin-4-receptor-alpha-still-required-after-th2-polarization

The protective role of oestradiol against silent myocardial ischemia and hypertension risk in South African men: The SABPA study

Malan NT, von Känel R, Steyn HS, Kruger R, Malan L.

https://www.ncbi.nlm.nih.gov/pubmed/28629624

/research-for-our-people/protective-role-oestradiol-against-silent-myocardial-ischemia-and

Changes in host immune-endocrine relationships during tuberculosis treatment in patients with cured and failed treatment outcomes

Kleynhans L, Ruzive S, Ehlers L, Thiart L, Chegou NN, Conradie M, Kriel M, Stanley K, van der Spuy GD, Kidd M, van Helden PD, Walzl G, Ronacher K.

https://www.ncbi.nlm.nih.gov/pubmed/28674532

/research-for-our-people/changes-host-immune-endocrine-relationships-during-tuberculosis-treatment

Efficacy of maternal influenza vaccination against all-cause lower respiratory tract infection hospitalizations in young infants: Results from a randomized controlled trial

Nunes MC, Cutland CL, Jones S, Downs S, Weinberg A, Ortiz JR, Neuzil KM, Simoes EAF, Klugman KP, Madhi SA

https://www.ncbi.nlm.nih.gov/pubmed/28575286

/research-for-our-people/efficacy-maternal-influenza-vaccination-against-all-cause-lower-respiratory

The incremental value of repeated induced sputum and gastric aspirate samples for the diagnosis of pulmonary tuberculosis in young children with acute community-acquired pneumonia

Moore DP, Higdon MM, Hammitt LL, Prosperi C, DeLuca AN, Da Silva P, Baillie VL, Adrian PV, Mudau A, Deloria Knoll M, Feikin DR, Murdoch DR, O'Brien KL, Madhi SA.

https://www.ncbi.nlm.nih.gov/pubmed/28575364

/research-for-our-people/incremental-value-repeated-induced-sputum-and-gastric-aspirate-samples

Diagnosis of pulmonary tuberculosis in HIV-infected and uninfected children using Xpert MTB/RIF ultra

Zar HJ, Workman L, Nicol MP.

http://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2017.195.1_MeetingAbstracts.A7610

/research-for-our-people/diagnosis-pulmonary-tuberculosis-hiv-infected-and-uninfected-children-using

Safety and immunogenicity of a parenteral P2-VP8-P[8] subunit rotavirus vaccine in toddlers and infants in South Africa: A randomised, double-blind, placebocontrolled trial

Groome MJ, Koen A, Fix A, Page N, Jose L, Madhi SA, McNeal M, Dally L, Cho I, Power M, Flores J, Cryz S.

https://www.ncbi.nlm.nih.gov/pubmed/28483414

/research-for-our-people/safety-and-immunogenicity-parenteral-p2-vp8-p8-subunit-rotavirus-vaccine

Psychiatric practice: Caring for patients, collaborating with partners, or marketing to consumers?

Stein DJ.

https://www.ncbi.nlm.nih.gov/pubmed/28498586

/research-for-our-people/psychiatric-practice-caring-patients-collaborating-partners-or-marketing

Assessing the complexity of interventions within systematic reviews: Development, content and use of a new tool (iCAT-SR). BMC Medical Research Methodology

Lewin S, Hendry M, Chandler J, Oxman AD, Michie S, Shepperd S, Reeves BC, Tugwell P, Hannes K, Rehfuess EA, Welch V, McKenzie JE, Burford B, Petkovic J, Anderson LM, Harris J, Noyes J.

https://www.ncbi.nlm.nih.gov/pubmed/28446138

/research-for-our-people/assessing-complexity-interventions-within-systematic-reviews-development

Age-dependent development of left ventricular wall thickness in type 2 diabetic (db/db) mice is associated with elevated low-density lipoprotein and triglyceride serum levels

Dludla PV, Essop MF, Gabuza KB, Muller CJ, Louw J, Johnson R.

https://www.ncbi.nlm.nih.gov/pubmed/28393273

/research-for-our-people/age-dependent-development-left-ventricular-wall-thickness-type-2-diabetic

Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion

Jackson CS, Durandt C, Janse van Rensburg I, Praloran V, Brunet de la Grange P, Pepper MS.

https://www.ncbi.nlm.nih.gov/pubmed/28445828

/research-for-our-people/targeting-aryl-hydrocarbon-receptor-nuclear-translocator-complex-dmog-and

Immunization with 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) according to different schedules in infants in South Africa: A phase III trial

Madhi SA, Koen A, Jose L, Moreira M, van Niekerk N, Cutland C, François N, Ruiz-Guiñazú J, Yarzabal JP, Borys D, Schuerman L.

https://www.ncbi.nlm.nih.gov/pubmed/28425818

/research-for-our-people/immunization-10-valent-pneumococcal-non-typeable-haemophilus-influenzae

Sustained inhibition of HBV replication in vivo after systemic injection of AAVs encoding artificial antiviral primary microRNAs

Maepa MB, Ely A, Grayson W, Arbuthnot P.

http://www.cell.com/molecular-therapy-family/nucleic-acids/pdfExtended/S2162-2531(17)30157-9

/research-for-our-people/sustained-inhibition-hbv-replication-vivo-after-systemic-injection-aavs

Impact of CYP2D6 genotype on amitriptyline efficacy for the treatment of diabetic peripheral neuropathy: A pilot study

Chaudhry M, Alessandrini M, Rademan J, Dodgen TM, Steffens FE, van Zyl DG, Gaedigk A, Pepper MS

https://www.ncbi.nlm.nih.gov/pubmed/28350251

/research-for-our-people/impact-cyp2d6-genotype-amitriptyline-efficacy-treatment-diabetic-peripheral

Recent advances in understanding hypertension development in sub-Saharan Africa

Schutte AE, Botha S, Fourie CM, Gafane-Matemane LF, Kruger R, Lammertyn L, Malan L, Mels CM, Schutte R, Smith W, van Rooyen JM, Ware LJ, Huisman HW.

https://www.ncbi.nlm.nih.gov/labs/articles/28332510/

/research-for-our-people/recent-advances-understanding-hypertension-development-sub-saharan-africa

Psychosocial group interventions to improve psychological well-being in adults living with HIV

van der Heijden I, Abrahams N, Sinclair D.

https://www.ncbi.nlm.nih.gov/pubmed/28291302

/research-for-our-people/psychosocial-group-interventions-improve-psychological-well-being-adults

Efficacy and safety of agomelatine (10 or 25 mg/day) in non-depressed out-patients with generalized anxiety disorder: A 12-week, double-blind, placebo-controlled study

Stein DJ, Ahokas A, Jarema M, Avedisova AS, Vavrusova L, Chaban O, Gruget C, Olivier V, Picarel-Blanchot F, de Bodinat C.

https://www.ncbi.nlm.nih.gov/pubmed/28298261

/research-for-our-people/efficacy-and-safety-agomelatine-10-or-25-mgday-non-depressed-out-patients

Cookstove options for safety and health: Comparative analysis of technological and usability attributes

Kimemia D, Van Niekerk A.

http://www.sciencedirect.com/science/article/pii/S0301421517301659

/research-for-our-people/cookstove-options-safety-and-health-comparative-analysis-technological-and