Page 143 - SAMRC Annual Report 2023-24

PERFORMANCE INFORMATION

The unit has secured new equipment such as capacity building, positioning us as international
the Matrix-Assisted Laser Desorption/Ionization leaders in the field of skin repair and regeneration.
(MALDI), xCELLigence Real Time Cell Analyzer,
LUMOS FTIR analysis and Agilent Seahorse XF In celebration of 30 years of
Extracellular Flux Analyse that is not available in democracy in South Africa
most SA universities, thus enhancing our state-of-
the-art facilities. Also, several patent submissions The unit’s identity and status are characterised
have been made for Phenyl-Pyrazolo[3,4-B] Pyridine- by its commitment to advancing knowledge and
4-Carboxylic Acid derivates for use as 5-Alpha capabilities in the field of skin biology, particularly
Reductase Antagonists in methods of treatment, in the areas of healing, regeneration, and scarring.
the creation of a Human Keloid Fibroblast Cell Line With a specialised focus on skin scarring and keloid
as well as a method and compounds for treating disease, our research employs a multifaceted
keloids, respectively. During the reporting period, approach utilising various in vitro, ex vivo, and
2 honours, 1 master’s and 2 doctoral students have sequential in vivo wound biopsy models in human
graduated, with 15 students obtaining an Advanced skin, to unravel the complex pathobiology underlying
Diploma in Cosmetic Formulation Science. In skin repair processes, with a particular emphasis on
addition, several past students/researchers trained identifying and evaluating targeted biomarkers and
within the unit have furthered their careers, therapeutic compounds aimed at enhancing scar
having moved on to or being promoted to other treatment, especially in pigmented skin.
opportunities, assuming positions as post-doctoral
fellows and a Senior Research Officer within the unit. Additionally, the unit is dedicated to furthering
The unit has also formed collaborations with the understanding in skin repair, fibrosis, and
Mechanical Engineering Department at UCT, as well regeneration, with a translational therapeutic focus
as Ohio State University (USA). on the development of skin substitutes. Furthermore,
it encompasses both basic and translational
Science for creating a research endeavours, with the overarching goal of
healthier society contributing to advancements in the diagnosis,

Our research has generated significant interest prevention, and treatment of skin conditions related
to healing, scarring, and regeneration.
and support from external industry collaborating
sponsors, resulting in additional funding and The receipt of the Extramural Research Chair in
opportunities for commercialisation. With a Wound Healing and Keloid Scarring from the
portfolio of 18 published manuscripts and ongoing SAMRC is a significant milestone for our research
collaborations, our research portfolio strengthens endeavours, and we are deeply grateful for this
the broader efforts of the Division of Dermatology in support. Additionally, while we have been able
advancing skin repair and regeneration. to conduct research in wound healing and keloid
scarring leveraging personnel and consumables
Central to our research endeavours is our
commitment to patient-centred care and inclusivity. from other projects, dedicated funding from the
We prioritise engagement with stakeholders across SAMRC enables us to significantly enhance our
various sectors, including industry, healthcare, efforts in this area.
academia, and patient advocacy groups, to ensure Looking ahead, we envision leveraging our expertise
that our research remains relevant and impactful. and resources to further expand our reach through
Moreover, we actively mentor and nurture the remote teaching links and placement opportunities,
next generation of researchers, both locally and
internationally, fostering a culture of excellence and facilitating wider collaboration and knowledge
collaboration. exchange. By capitalising on our strengths in wound
healing and keloid scarring management, we aim
In summary, our research programmes not only to not only advance scientific understanding but
address critical healthcare challenges in South Africa also contribute to education, training, and income
but also fosters innovation, collaboration, and generation opportunities.

SAMRC ANNUAL REPOR T 2023-24 141