Page 146 - SAMRC AnnualReport 2025-26

and improve animal welfare, while repairs and These findings are expected to deepen
refurbishments of rhesus macaque outdoor understanding of how helminth infections modulate
enclosures were initiated to ensure continued immune responses and may guide the optimisation
compliance. To further support high-quality of HIV and other vaccines, especially in regions
research, dedicated HVAC systems were installed where helminth infections are endemic.
in immunology, vaccinology, and molecular biology
laboratories, fostering controlled environments Overall, these efforts have strengthened PUDAC's
essential for advanced research. research platform, enhanced its contribution to
translational science, and improved prospects for
Simultaneously, PUDAC advanced several key collaborative research and sustainable funding.
research projects targeting critical health issues. The strategic infrastructure upgrades and targeted
Research on African Traditional Medicines (ATMs)
examined their effects on cardiovascular diseases, health research initiatives position PUDAC to
aiming to identify therapeutic interventions to effectively tackle urgent health challenges while
address the rising burden of non-communicable expanding its scientific impact and international
diseases (NCDs). partnerships.

Complementary studies focused on identifying Building Capacity Through
inhibitors of Cathepsin S using in vitro models, Training, Mentorship, and Support
contributing to the development of novel treatment
strategies supported by publishable findings. Capacity and skills development at PUDAC
Another significant project examined the impact of remains a key priority, with a strong focus on
helminth infections on the efficacy of HIV vaccine empowering both staff and emerging researchers
candidates, in collaboration with the University of while promoting equity and dignity in health
Cape Town. Using rhesus macaque models and research. This commitment is reflected in sustained
Schistosoma mansoni as a prototype helminth, investment in postgraduate training, skills
the study evaluated how co-infections influence development, and professional advancement.
immune responses and vaccine effectiveness. During the reporting period, a PhD student
Advanced techniques, including next-generation successfully graduated, contributing valuable new
RNA sequencing, characterised transcriptional knowledge to biomedical research. A second PhD
profiles and identified key immunological pathways candidate submitted her thesis for examination,
affected by helminthic parasites. while a third is in the final write-up stage. These
achievements highlight PUDAC's role in developing
highly skilled researchers and fostering an inclusive
academic environment that supports knowledge
generation and transformation. Through
collaborations with academic institutions, the unit
continues to create opportunities for students from
diverse backgrounds to participate meaningfully in
advanced scientific research.
In parallel, PUDAC invested in the professional
development of its technical staff. Six staff
members were enrolled in the Institute of Animal
Technology (IAT) training programme through
Cambridge, with three successfully completing
the Level 2 Diploma during the reporting period.
This specialised training strengthens competencies
in laboratory animal care, welfare, and research
support, reinforcing ethical research practices and
ensuring that animal use is conducted with respect,
care, and scientific responsibility.

Vevo F2 ultrasound imaging system for These initiatives collectively build local capacity and
small an large laboratory animals.
advance equitable participation in health research
by equipping individuals with critical skills and

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