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Current Projects

South African National Tuberculosis Prevalence Survey

Project PI - Prof vd Walt

The first South African National Tuberculosis Survey was conducted between August 2017 and July 2029 with the aim to enhance TB control in South Africa by informing the National TB Control Programme about the current epidemiological situation of TB disease and offering insight on ways in which TB control can be improved.

Global Fund and Bill and Melinda Gates Foundation

Evaluation of Computer Automated Reading Software in Detecting Tuberculosis from Chest X-Ray in Prevalence Setting

Project PI - Prof vd Walt

To fill the evidence gap in the use of chest X-rays in TB screening, we will compare the performance of three different Deep Learning applications in detecting bacteriologically confirmed TB with that of radiologists experienced in detecting TB, using datasets from the latest prevalence survey from South Africa.


Diagnostic and therapeutic biomarker responses in HIV and tuberculosis coinfected patients

PhD thesis

Project PI - T Mthiyane

We describe the benefit of 1) urine lipoarabinomannan (LAM) to diagnose TB in smear-negative HIV infected patients 2) N-acetyl transferase 2 (NAT2) polymorphisms and TB treatment response, 3) Quantiferon Gold in tube (QFT-GIT) to monitor response to treatment in smear and culture positive TB-HIV coinfected patients, and 4) a quality of life instrument to monitor treatment response as biomarkers for use in patients.