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Precision Oncology

Current Projects

  • Identify and comprehensively characterise the potential common and country-specific risk factors underlying high cervical and oesophageal cancer incidences and mortality rates in South Africa, Brazil, China, India and Tanzania.
  • Define the RNA and splicing landscape of cervical and oesophageal cancers to determine whether splicing and expression alterations differ between and among populations from Low- Middle Income Countries (LMICs) and developed countries by comparing patient samples from South Africa, China, India, Brazil and Tanzania.
  • Investigate the therapeutic potential of miRNAs and their mRNA and pathway targets in HIV-associated cervical and oesophageal cancer.
  • Conduct pre-clinical and clinical trials of natural products to investigate the anti- tumour and anti-metastasis efficacy using tumour grafts (TGs) or patient derived xenografts (PDXs).