- Temporal changes of Streptococcus pneumoniae and other bacterial pharyngeal colonization in children and adults in urban and rural South African settings with high HIV-prevalence, in the era of childhood pneumococcal conjugate vaccine immunization.
- Evaluation of reduced dosing schedule of pneumococcal conjugate vaccine: possibility of changing to a single primary dose and a subsequent booster dose.
- Establishing correlate of protection against invasive Group B. streptococcus disease in infants, as a potential pathway to licensure of a GBS vaccine in pregnant women.
- A Double-blind, Randomized, Placebo-controlled, Single Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of MK-1654 in Pre-Term and Full-Term Infants.