My work leverages the complex ancestry of South Africans to find novel genes and pathways involved in tuberculosis (TB) resistance or susceptibility. Combining these interests with my insights into the latest genetic analyses available have allowed the work on genetic susceptibility to TB to benefit from population genetic and sex-specific analyses as well as next generation sequencing. With collaborators, we have developed protocols for TB status and DNA collection for population genetics in the Northern Cape, while facilitating community return of genetic results. As part of this project community members were trained to assist with participant recruitment. I am also a member of PIDDGEN, a research group that aims to profile the genetic causes of primary immunodeficiencies (PID) in South Africa. This has moved our group into the precision medicine space giving our research translational impact. Our experience in the human genetic susceptibility to infectious diseases field allowed us to generate the first human whole genome sequencing from African participants with severe COVID-19 phenotypes, that may impact on local vaccination strategies. Importantly, we have developed tools, such as a population-specific reference genome, recombination maps and ancestry informative marker panels. This impacts on all genetic studies of disease in local South African populations.